Written in English
Bipolar disorder and opioid use disorders are highly co-morbid. Evidence from past opioid agonist challenge studies conducted in unipolar and bipolar depressed subjects suggest transient global improvements in depressive symptoms. It was hypothesized that persons experiencing bipolar depression would exhibit altered responses to acute opioid exposure, experiencing greater changes in mood compared to control subjects. Fifteen bipolar (8 euthymic, 7 depressed), and 10 control subjects participated in a double-blind, placebo-controlled, randomized, cross-over study. Subjective and physiological effects of hydromorphone 6 mg orally were assessed over 6 hours. Results demonstrated that bipolar I depressed subjects reported improved mood associated with hydromorphone. Adverse effects of hydromorphone negatively correlated with depression severity. These findings support the hypothesis that individuals experiencing bipolar depression may exhibit an altered response to acute hydromorphone exposure and suggest that this altered response is likely related to the state of depression rather than to the vulnerability for bipolar disorder.
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In this broad conceptualization of bipolar disorder and substance use, regarding opioids, it cannot be rule out the possibility that bipolar heroin addicts use heroin in a self-therapeutic manner. Bipolar Disorder Journal Articles Medication-Assisted Treatment for Opioid Use Disorder What factors might contribute to the under-utilization of medication-assisted treatment. Sarah A. L. Marshall has written: 'Probing acute opioid effects in bipolar disorder' Asked in Depression and Bipolar Disorder What body systems are affected by bipolar disorder? If you're considering opioid pain medicine for chronic pain, read this Q&A with a physical therapist about the benefits that physical therapy can offer as an alternative to opioids.
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